100000 - Document - Document and Entity Information
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100010 - Statement - Balance Sheets
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100020 - Statement - Balance Sheets (Parenthetical)
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100030 - Statement - Statements of Operations and Comprehensive Loss
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100040 - Statement - Statements of Stockholders' Equity
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100050 - Statement - Statements of Cash Flows
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995455 - Disclosure - Description of Business
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995465 - Disclosure - Basis of Presentation and Significant Accounting Policies
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995475 - Disclosure - Net Loss Per Share
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995485 - Disclosure - Fair Value of Financial Instruments
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995495 - Disclosure - Balance Sheet Components
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995505 - Disclosure - Leases
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995515 - Disclosure - Commitments and Contingencies
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995525 - Disclosure - Collaboration and License Agreements
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995535 - Disclosure - Employee Benefits
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995545 - Disclosure - Stockholders' Equity
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995555 - Disclosure - Share-Based Compensation
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995565 - Disclosure - Income Taxes
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995575 - Disclosure - Reduction in Force
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995585 - Disclosure - Basis of Presentation and Significant Accounting Policies (Policies)
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995595 - Disclosure - Net Loss Per Share (Tables)
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995605 - Disclosure - Fair Value of Financial Instruments (Tables)
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995615 - Disclosure - Balance Sheet Components (Tables)
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995625 - Disclosure - Leases (Tables)
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995635 - Disclosure - Share-Based Compensation (Tables)
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995645 - Disclosure - Income Taxes (Tables)
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995655 - Disclosure - Description of Business - Additional Information (Details)
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995665 - Disclosure - Basis of Presentation and Significant Accounting Polices - Additional Information (Details)
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995675 - Disclosure - Net Loss Per Share - Computation of Basic and Diluted Net Loss Per Share (Details)
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995685 - Disclosure - Net Loss Per Share - Summarizes the Outstanding Potentially Dilutive Securities Excluded in Calculation of Diluted Net Loss Per Share (Details)
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995695 - Disclosure - Fair Value of Financial Instruments - Summary of Fair Value of Financial Instrument (Details)
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995705 - Disclosure - Fair Value of Financial Instruments - Additional Information (Details)
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995715 - Disclosure - Fair Value of Financial Instruments - Schedule of Short-term Investments (Details)
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995725 - Disclosure - Fair Value of Financial Instruments - Schedule of Change in Preferred Stock Purchase Right Liability (Details)
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995735 - Disclosure - Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Details)
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995745 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment, Net (Details)
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995755 - Disclosure - Balance Sheet Components - Additional Information (Details)
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995765 - Disclosure - Balance Sheet Components - Schedule of Accrued and Other Current Liabilities (Details)
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995775 - Disclosure - Leases - Components of Lease Expense (Details)
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995785 - Disclosure - Leases - Schedule of Supplemental Information Related to Operating Leases (Details)
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995795 - Disclosure - Leases - Additional Information (Details)
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995805 - Disclosure - Leases - Schedule of Maturities of Operating Lease Liabilities (Details)
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995815 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995825 - Disclosure - Leases - Schedule of Maturities of Operating Lease Liabilities (Details) 2
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995835 - Disclosure - Collaboration and License Agreements - Additional Information (Details)
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995845 - Disclosure - Employee Benefits - Additional Information (Details)
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995855 - Disclosure - Stockholders' Equity (Details)
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995865 - Disclosure - Share-Based Compensation - Additional Information (Details)
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995875 - Disclosure - Share-Based Compensation - Summary of Stock Option Activity (Details)
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995885 - Disclosure - Share-Based Compensation - Summary of Additional Information Related to Stock Options (Details)
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995895 - Disclosure - Share-Based Compensation - Summary of Restricted Stock Unit Activity (Details)
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995905 - Disclosure - Share-Based Compensation - Summary of Common Stock Reserved for Future Issuance (Details)
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995915 - Disclosure - Share-Based Compensation - Summary of Share-based Compensation Expense (Details)
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995925 - Disclosure - Share-Based Compensation - Schedule of Fair Value of Stock Options Estimated on Date of Grant Using Quoted Market Price For Common Stock On The Applicable Grant Date And Black-Scholes Option Pricing Model (Details)
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995935 - Disclosure - Income Taxes - Additional Information (Details)
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995945 - Disclosure - Income Taxes - Reconciliation on Income Taxes Amount Computed by Applying Statutory Federal Income Tax Rate to Net Loss (Details)
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995955 - Disclosure - Income Taxes - Significant Components of Deferred Tax Assets (Details)
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995965 - Disclosure - Income Taxes - Summary of Changes in Gross Unrecognized Tax Benefits (Details)
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995975 - Disclosure - Reduction in Force - Additional Information (Details)
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Auditor Firm ID
2024
Lessee, Operating Lease, Liability, to be Paid, Year One
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Document Transition Report
Document Transition Report
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-average remaining contractual term (in years), outstanding balance
Money Market Funds [Member]
Money Market Funds
Increase in share limit as percentage of outstanding shares of common stock on last trading day in prior year.
Increase In Share Limit As Percentage Of Outstanding Shares Of Common Stock On Last Trading Day In Prior Year
Increase in share limit as percentage of outstanding shares of common stock on last trading day in prior year
Number of non exclusive rights to gene editing targets licenses received.
Number Of Non Exclusive Rights To Gene Editing Targets licenses received
Number of non-exclusive rights to gene editing targets licenses received
Percentage of reduction
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Net unrealized gain (loss) on investments
Unrealized Gain (Loss) on Investments
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Schedule of Change in Preferred Stock Purchase Right Liability
Debt Securities, Available-for-sale, Total
Debt Securities, Available-for-Sale
Available for sale securities,Estimated Fair Value
Other Current Assets
Other Current Assets [Member]
Fair value measurement with unobservable inputs reconciliations Reclassification of preferred stock purchase right liability to equity upon issuance of convertible preferred stock.
Fair Value Measurement With Unobservable Inputs Reconciliations Reclassification Of Preferred Stock Purchase Right Liability To Equity Upon Issuance Of Convertible Preferred Stock
Reclassification of preferred stock purchase right liability to equity upon issuance of convertible preferred stock
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Weighted Average Number of Shares Issued, Basic
Weighted average common shares outstanding
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Restricted Stock Unit Activity
Fair Value, Inputs, Level 1 [Member]
Quoted Prices in Active Markets for Identical Assets (Level 1)
Temporary Equity, Stock Issued During Period, Value, New Issues
Temporary equity, Issuance of Series B convertible preferred stock, net of issuance costs
Entity Public Float
Entity Public Float
2027
Lessee, Operating Lease, Liability, to be Paid, Year Four
Operating Lease, Liability [Abstract]
Operating lease liabilities:
Fair Value Disclosures [Text Block]
Fair Value of Financial Instruments
ROU assets obtained in exchange for operating lease liabilities resulting from new leases
Right-of-use assets obtained in exchange for operating lease liabilities resulting from new leases.
Right-of-use Assets Obtained in Exchange for Operating Lease Liabilities Resulting from New Leases
Income Tax, Policy [Policy Text Block]
Income Taxes
Property, Plant and Equipment, Useful Life
Estimated useful lives of assets
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration revenue
Product revenue
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized compensation cost
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance of net deferred tax assets
Receivable under research cost sharing provision
Receivable Under Research Cost Sharing Provision
Receivable under research cost sharing provision.
Short-Term Debt, Type [Axis]
ICFR Auditor Attestation Flag
Lease liabilities arising from obtaining right-of-use assets
Lease Liabilities Arising From Obtaining Right Of Use Assets [Abstract]
Lease liabilities arising from obtaining right-of-use assets
Deferred tax assets depreciation and amortization.
Deferred Tax Assets Depreciation And Amortization
Depreciation and amortization
Cash paid for amounts included in the measurement of lease liabilities.
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Cash paid for amounts included in the measurement of lease liabilities
Schedule of share based compensation additional information related to stock options.
Schedule Of Share Based Compensation Additional Information Related To Stock Options
Summary of Additional Information Related to Stock Options
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Summary of Share-based Compensation Expense
Title of Individual [Domain]
Title of Individual
Weighted average number of shares unvested common stock issued upon early exercise of common stock options.
Weighted Average Number Of Shares Unvested Common Stock Issued Upon Early Exercise Of Common Stock Options
Less: weighted average unvested common stock issued upon early exercise of common stock options
Temporary Equity, Shares Issued
Convertible preferred stock, shares issued
Temporary equity, shares issued
MaxCyte License Agreement
MaxCyte License Agreement [Member]
MaxCyte license agreement.
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Non-current
Schedule of Stock by Class [Table]
Schedule Of Stock By Class [Table]
Initial Lease Agreement And Additional Lease Agreement.
Initial Lease Agreement And Additional Lease Agreement [Member]
Initial Lease Agreement and Additional Lease Agreement
Assets, Fair Value Disclosure [Abstract]
Assets:
Class of Stock [Line Items]
Class Of Stock [Line Items]
Amounts owed under the agreement
Amounts Owed Under Agreement
Amounts owed under agreement.
Balance Sheet Location [Axis]
Assets, Current
Total current assets
Total liabilities and stockholders' equity
Liabilities and Equity
Entity Address, State or Province
Entity Address, State or Province
Deferred Tax Assets, Other
Other, net
Issuance of common stock, net of issuance costs
Issuance of common stock, net of issuance costs
Stock Issued During Period, Value, New Issues
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split, conversion ratio
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of shares, outstanding ending balance
Number of shares, outstanding beginning balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant-date fair value of stock option grants per share
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Trading Symbol
Trading Symbol
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax assets, net of valuation allowance
Net deferred tax asset
Temporary equity stock issued during period value upon conversion of promissory notes.
Temporary Equity Stock Issued During Period Value Upon Conversion Of Promissory Notes
Temporary equity, issuance of Series B convertible preferred stock upon conversion of promissory notes
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common stock, shares issued
Shares issued during period
Fair value of restricted stock units vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Corporate office and laboratory facilities.
Corporate Office And Laboratory Facilities [Member]
Corporate Office and Laboratory Facilities
Compensation and Employee Benefit Plans [Text Block]
Employee Benefits
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Shares, Outstanding
Ending Balance, Shares
Beginning Balance, Shares
Net operating loss and tax credit carryforwards to offset.
Net Operating Loss And Tax Credit Carryforwards To Offset [Member]
Net Operating Loss and Tax Credit Carryforwards to Offset
2026
Lessee, Operating Lease, Liability, to be Paid, Year Three
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for future issuance
Number of common stock available for issuance
Number of position reduced
Restructuring and Related Cost, Number of Positions Eliminated
Income tax reconciliation change in fair value of derivative liability.
Income Tax Reconciliation Change In Fair Value Of Derivative Liability
Change in fair value of derivative liabilities
Accumulated Other Comprehensive Income (Loss)
AOCI Attributable to Parent [Member]
Entity Address, City or Town
Entity Address, City or Town
Proceeds from at the market offering net of issuance costs.
Proceeds From At The Market Offering Net of Issuance Costs
Proceeds from ATM offering, net of issuance costs
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate
Lessee, Operating Lease, Renewal Term
Renewal term
Rule 10b5-1 Arrangement Modified
Rule 10b5-1 Arr Modified [Flag]
Rule 10b5-1 Arr Modified Flag.
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Subsequent Event [Member]
Subsequent Event
Subsequent Event Type [Axis]
Subsequent Event Type
Cash cash equivalents restricted cash and short term investments.
Cash Cash Equivalents Restricted Cash And Short Term Investments
Cash, cash equivalents restricted cash and short-term investments
Additional Paid-in Capital [Member]
Additional Paid-In Capital
Percentage of sublicensing income.
Percentage Of Sublicensing Income
Percentage of sublicensing income
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Liabilities, Current [Abstract]
Current liabilities:
U.S. Government securities
US Government Corporations and Agencies Securities [Member]
Assets, Current [Abstract]
Current assets:
Counterparty Name [Axis]
Counterparty Name
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment, Long-Lived Asset, Held-for-Use
Impairment losses on long-lived assets
Statement of Stockholders' Equity [Abstract]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted-average exercise price, vested and expected to vest
Research equipment.
Research Equipment [Member]
Research Equipment
Operating Lease, Liability, Current
Operating lease liabilities, current portion
Current
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Class of Stock [Domain]
Class of Stock
Scenario [Domain]
Scenario
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Issuance of common stock upon vesting of restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Plan Name [Domain]
Plan Name
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Weighted-average remaining contractual term (in years), outstanding ending balance
Restricted Cash, Noncurrent
Restricted cash
Assets, Fair Value Disclosure
Total
Lessee, Operating Lease, Option to Extend
Lessee option to extend description
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Liabilities, Current
Total current liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Schedule of prepaid expenses and other current assets.
Schedule Of Prepaid Expenses And Other Current Assets Table [Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Financial Instruments [Domain]
Financial Instruments
Share-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Increases (decreases) related to tax positions taken in prior years
Unrecognized Tax Benefits Increases Decreases Resulting From Prior Period Tax Positions
Unrecognized tax benefits increases (decreases) resulting from prior period tax positions.
Construction in Progress [Member]
Construction in Progress
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock upon employee stock purchase plan
Lessee, Operating Leases [Text Block]
Leases
Restricted Stock [Member]
Restricted Stock Options
Plan Name [Axis]
Plan Name
Letter of credit notice period by financial institution before annual expiration date.
Letter Of Credit Notice Period By Financial Institution Before Annual Expiration Date
Letter of credit notice period by financial institution before annual expiration date
Operating lease receivable
Operating Leases, Future Minimum Payments Receivable, Current
Vivarium.
Vivarium [Member]
Vivarium
Lessee, operating lease, term of contract
Lessee, Operating Lease, Term of Contract
Assets
Total assets
GlaxoSmithKline Intellectual Property Development Limited and Glaxo Group Limited.
Glaxo Smith Kline Intellectual Property Development Limited And Glaxo Group Limited [Member]
GSK
Investment Income, Net, Total
Investment Income, Net
Interest income
Right-of-use assets
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Dividend, Share-based Payment Arrangement, Total
Dividend, Share-Based Payment Arrangement
Dividends issued for options
Entity Registrant Name
Entity Registrant Name
Components of Deferred Tax Assets [Abstract]
Deferred tax assets:
Issuance and sale of equity
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Lessee, Operating Lease, Existence of Option to Extend [true false]
Operating lease, existence of option to extend
Fair value of preferred stock purchase right liability percentage.
Fair Value Of Preferred Stock Purchase Right Liability Percentage
Fair value of preferred stock purchase right liability percentage
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Proceeds from Stock Plans
Proceeds from ESPP purchases
Aggregate cash proceeds
Supplemental disclosures of non-cash investing activities:
Supplemental Cash Flow Information [Abstract]
Retained Earnings [Member]
Accumulated Deficit
Deferred tax liabilities depreciation and amortization.
Deferred Tax Liabilities Depreciation And Amortization
Depreciation and amortization
Class of Stock [Axis]
Class of Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of shares, outstanding beginning balance
Number of shares, outstanding ending balance
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income tax benefit at statutory rates
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock upon employee stock purchase plan,share
Minimum [Member]
Minimum
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Significant Accounting Policies [Text Block]
Basis of Presentation and Significant Accounting Policies
Lease liabilities
Operating Lease, Liability
Total lease liability
Total operating lease liabilities
401 (K) Plan.
K Plan [Member]
401 (K) Plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility, minimum
U.S. Government securities
US Government Agencies Debt Securities [Member]
Equity Component [Domain]
Equity Component
Defined Contribution Plan, Cost
Expense contribution plan
Options
Conversion of Stock, Shares Converted
Temporary equity, conversion of convertible preferred stock to common stock, Shares
Debt Securities, Available-for-Sale, Sold at Par Value
Investments sold
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Preferred stock purchase right liability.
Preferred Stock Purchase Right Liability Policy [Text Block]
Preferred Stock Purchase Right Liability
Carry forward indefinitely.
Carry Forward Indefinitely [Member]
Carry Forward Indefinitely
License agreement.
License Agreement [Member]
License Agreement
Entity Current Reporting Status
Entity Current Reporting Status
Common Stock, Shares Authorized
Common stock, shares authorized
Research and Development Expense, Total
Research and Development Expense
Research and development
Research and development costs
Lease expiration month and year.
Lease Expiration Month And Year
Lease expiration month and year
Temporary equity, reacquisition of beneficial conversion feature upon settlement of promissory notes.
Temporary Equity Reacquisition Of Beneficial Conversion Feature Upon Settlement Of Promissory Notes
Temporary equity, reacquisition of beneficial conversion feature upon settlement of promissory notes
Assets [Abstract]
Assets
Proceeds from Issuance of Common Stock
Net proceeds from public offering
Net proceeds from offering
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
2021 Shelf Registration Statement
Two Thousand And Twenty One Shelf Registration Statement [Member]
2021 Shelf registration statement.
Collaboration and license agreement.
Collaboration And License Agreement [Member]
Collaboration and License Agreement
Interest Receivable, Current
Accrued interest receivable
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Common stock, $0.0001 par value; 100,000,000 shares authorized; 49,181,295 and 48,877,806 shares issued and outstanding at December 31, 2023 and 2022, respectively
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Other Noncash Income (Expense), Total
Other Noncash Income (Expense)
Others
Restructuring reserve
Restructuring Reserve
Restructuring Reserve, Ending Balance
Restructuring Reserve, Beginning Balance
Restructuring Reserve, Total
Furniture and Fixtures [Member]
Furniture and Fixtures
Accrued Liabilities, Current, Total
Accrued Liabilities, Current
Accrued and other current liabilities
Second amendment of additional lease agreement.
Second Amendment Of Additional Lease Agreement [Member]
Second Amendment Of Additional Lease Agreement
Current Fiscal Year End Date
Current Fiscal Year End Date
Share-based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Share-based compensation expense
Auditor Name
Tax credit carryforward expiration year.
Tax Credit Carryforward Expiration Year
Tax credit carryforwards, expire
Operating Income (Loss)
Loss from operations
ASU 2019-12
Accounting Standards Update 2019-12 [Member]
Realized (gain) loss on investments
Debt Securities, Available-for-sale, Realized Gain (Loss), Total
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Realized gain or loss on available-for-sale securities
Expected base rent over the lease term.
Expects to pay base rent over the lease term
Expected Base Rent Over Lease Term
Entity Ex Transition Period
Entity Ex Transition Period
Tax Period [Axis]
Tax Period
Income Tax Expense (Benefit)
Income tax expense
Provision or benefit for income taxes
Operating loss carryforwards, expiration year.
Operating Loss Carryforwards Expiration Year
Net operating loss carryforwards, expire
Deferred Offering Costs
Deferred offering costs
Research and Development Expense [Member]
Research and Development
Lessee, Leases [Policy Text Block]
Leases
Payments for restructuring
Payments for Restructuring
Milestone payment upon completion of regulatory milestone related to the clinical development.
Milestone Payment Upon Completion Of Regulatory Milestone Related To Clinical Development
Milestone payment
Share-Based Payment Arrangement, Expense
Share-based compensation expense
Share-based compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility, maximum
Schedule of supplemental information related to operating leases.
Schedule Of Supplemental Information Related To Operating Leases Table [Text Block]
Schedule of Supplemental Information related to Operating Leases
Potential milestone payments.
Potential Milestone Payments
Potential milestone payments
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Accounting policies.
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Separation and release agreement.
Separation And Release Agreement [Member]
Separation and Release Agreement
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate intrinsic value, outstanding balance
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Reconciliation of cash, cash equivalents and restricted cash to the balance sheets:
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Lease expiration year.
Lease Expiration Year
Lease expiration year
Increases related to tax positions taken in current year
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Additions for tax positions taken in current year
Commitments and Contingencies, Policy [Policy Text Block]
Commitments
Corporate office and laboratory space.
Corporate Office And Laboratory Space [Member]
Corporate Office and Laboratory Space
Other expense, net
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense), net
Sale of Stock, Price Per Share
Stock public offering price
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Change in fair value of preferred stock purchase right liability
Change in fair value of preferred stock purchase right liability
Operating Expenses [Abstract]
Operating expenses:
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization expense
Entity Voluntary Filers
Entity Voluntary Filers
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Other comprehensive loss:
Debt Securities, Available-for-Sale [Table Text Block]
Schedule of Short-term Investments
Employee stock purchase plan look-back period.
Employee stock purchase plan look-back period
Commitments and Contingencies Disclosure [Abstract]
Other Assets, Noncurrent, Total
Other Assets, Noncurrent
Other long-term assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of shares, granted
Equity [Text Block]
Stockholders' Equity
Retirement Plan Type [Domain]
Retirement Plan Type
Accounting policies.
Accounting Policies [Table]
Accounting Policies [Table]
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Available for sale securities, Unrealized Gains
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
2029 and thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Lease, Cost [Table Text Block]
Components of Lease Expense
Preferred stock purchase right liability fair value disclosure.
Preferred Stock Purchase Right Liability Fair Value Disclosure
Preferred stock purchase right liability
Lease Contractual Term [Domain]
Earnings Per Share [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Maturities of Operating Lease Liabilities
Loss Contingencies [Table]
Loss Contingencies [Table]
Accounting Policies [Abstract]
Expiration year two.
Expiration Year Two [Member]
2036
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Share based compensation arrangement by share based payment award fair value assumptions common stock fair value.
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Common Stock Fair Value
Common stock fair value
Fair value of preferred stock purchase right liability outstanding term.
Fair Value Of Preferred Stock Purchase Right Liability Outstanding Term
Fair value of preferred stock purchase right liability outstanding term
Income taxes.
Income Taxes [Line Items]
Income Taxes [Line Items]
Scenario [Axis]
Scenario
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
ROU asset
Deferred tax liabilities right of use asset.
Deferred Tax Liabilities Right Of Use Asset
Temporary equity beneficial conversion feature upon issuance of convertible.
Temporary Equity Beneficial Conversion Feature Upon Issuance Of Convertible
Temporary equity, beneficial conversion feature upon issuance of convertible
Common stock options and restricted stock units.
Common Stock Options And Restricted Stock Units [Member]
Common Stock Options And Restricted Stock Units Granted And Outstanding
Temporary equity reclassification of preferred stock purchase right liability to equity upon issuance of convertible preferred stock.
Temporary Equity Reclassification Of Preferred Stock Purchase Right Liability To Equity Upon Issuance Of Convertible Preferred Stock
Reclassification of preferred stock purchase right liability to equity upon issuance of convertible preferred stock
Lessee, Operating Lease, Remaining Lease Term
Lease term
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, basic
Net loss per share, basic
Commitments and Contingencies
Commitments and contingencies (Note 7)
Changes in ownership by stockholders holding percentage.
Changes In Ownership By Stockholders Holding Percentage
Changes in ownership by stockholders holding percentage
Debt Securities, Available-for-Sale, Term
Available-for-sale securities, Maturity (in years)
Income Statement [Abstract]
Temporary equity stock issued during period shares upon conversion of promissory notes.
Temporary Equity Stock Issued During Period Shares Upon Conversion Of Promissory Notes
Temporary equity, issuance of Series B convertible preferred stock upon conversion of promissory notes, Shares
Operating Lease, Cost
Operating lease expense
Short-Term Lease, Cost
Short-term lease expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Unrecognized tax benefits, penalties and interest expense
Retirement Benefits [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Number of shares, vested and expected to vest
Statistical Measurement [Domain]
Statistical Measurement
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Document Period End Date
Document Period End Date
Statistical Measurement [Axis]
Statistical Measurement
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Operating Lease, Payments
Operating cash flows used for operating leases
Amount held as collateral for letters of credit issued to landlord.
Amount held as collateral for letters of credit issued to landlord
Amount paid under the agreement
Payments Made Under Collaborative Arrangement
Payments made under collaborative arrangement.
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, diluted
Net loss per share, diluted
Product and Service [Domain]
Product and Service
Lease, Cost [Abstract]
Lease, Cost [Abstract]
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carry forwards
Unrecognized Tax Benefits
Balance at the end of the year
Balance at the beginning of the year
Gross unrecognized tax benefits
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of shares, exercisable
Expiration year one.
Expiration Year One [Member]
2035
Two thousand twenty performance incentive plan.
Two Thousand Twenty Performance Incentive Plan [Member]
2020 Plan
Reserved for Future Equity Award Grants
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock
Additional paid-in capital
Fair value of preferred stock purchase right liability discount rate.
Fair Value Of Preferred Stock Purchase Right Liability Discount Rate
Fair value of preferred stock purchase right liability discount rate
Deferred Tax Assets, Net
Net deferred tax assets
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Employer contribution, percent
Investment, Type [Extensible Enumeration]
Issuance of common stock upon exercise of stock option , Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Number of shares, exercised
License and Maintenance [Member]
License Maintenance Fees
Common stock options.
Common Stock Options [Member]
Common Stock Options
Liabilities, convertible preferred stock and stockholders' equity
Liabilities and Equity [Abstract]
Payments of deferred offering costs
Payments of Deferred Offering Costs
Payments of deferred offering costs.
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Interactive Data Current
Entity Interactive Data Current
Private Placement [Member]
Secondary Offering
Underwriters Option to Purchase Additional Shares
Over-Allotment Option [Member]
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Abstract]
Equity [Abstract]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less imputed interest
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of shares, granted
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Deferred tax assets lease liability.
Deferred Tax Assets Lease Liability
Lease liability
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-average exercise price, exercised
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
License agreement term.
License Agreement Term
License agreement term
Equity Components [Axis]
Equity Components
Reduction of research and development expense resulting from partial reimbursement.
Reduction Of Research And Development Expense Resulting From Partial Reimbursement
Reduction of research and development expense resulting from partial reimbursement
Two thousand fifteen equity incentive plan.
Two Thousand Fifteen Equity Incentive Plan [Member]
2015 Plan
Proceeds from sales and maturities of investments
Proceeds from Sale, Maturity and Collection of Investments
Proceeds from Sale, Maturity and Collection of Investments, Total
Weighted-average grant date fair value per share, vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Local Phone Number
Local Phone Number
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Sale of Stock [Axis]
Sale of Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted-average exercise price, exercisable
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Maximum monthly base rent after increase on annual basis
Maximum Monthly Base Rent After Increase on Annual Basis
Maximum monthly base rent after increase on annual basis.
Research Tax Credit Carryforward [Member]
Research and Development Credit Carry Forwards
Issuance of common stock upon vesting of restricted stock units, Shares
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Statement of Cash Flows [Abstract]
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Reverse stock split policy.
Reverse Stock Split Policy Policy [Text Block]
Reverse Stock Split
Initial Lease Agreement
Initial Lease Agreement [Member]
Initial lease agreement.
Percentage of Licensors royalties.
Percentage Of Licensors Royalties
Percentage of licensors royalties
Income Tax Authority [Domain]
Income Tax Authority
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated other comprehensive income (loss)
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Deferred Charges, Policy [Policy Text Block]
Deferred Offering Costs
Document Annual Report
Document Annual Report
National University of Singapore and St. Jude Children's Research Hospital.
National University Of Singapore And St Jude Children S Research Hospital [Member]
NUS and St. Jude
Accounts Payable and Other Accrued Liabilities, Current
Other accrued and current liabilities
Common Stock, Par or Stated Value Per Share
Common stock, par value
Stock issued during period value vesting of shares of common stock subject to repurchase.
Stock Issued During Period Value Vesting Of Shares Of Common Stock Subject To Repurchase
Vesting of shares of common stock subject to repurchase
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation cost, expected to be recognized over weighted average remaining service period
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-average remaining contractual term (in years), vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of common stock authorized for issuance
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Temporary equity.
Temporary Equity Policy [Text Block]
Convertible Preferred Stock
Collaborartive Arrangements
Collaboration and License Agreements
Collaborative Arrangement Disclosure [Text Block]
Maximum [Member]
Maximum
2023 Shelf Registration Statement
Two Thousand And Twenty Three Shelf Registration Statement [Member]
2023 Shelf registration statement.
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Description of Business
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Summary of Changes in Gross Unrecognized Tax Benefits
Fair Value, Inputs, Level 3 [Member]
Significant Unobservable Inputs (Level 3)
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Share-based compensation expense
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Short-Term Debt, Type [Domain]
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net decrease in cash and cash equivalents
General and Administrative Expense [Member]
General and Administrative
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of shares, forfeited
Document Financial Statement Error Correction [Flag]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summarizes the Outstanding Potentially Dilutive Securities Excluded in Calculation of Diluted Net Loss Per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Payments
Dividends expected to be issued over life of options
Additional tenant improvement allowances.
Additional Tenant Improvement Allowances
Additional tenant improvement allowances
Fair Value, by Balance Sheet Grouping [Table Text Block]
Summary of Fair Value of Financial Instrument
City Area Code
City Area Code
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities:
Letter of Credit
Letter of Credit [Member]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation and amortization
General and Administrative Expense, Total
General and Administrative Expense
General and administrative
Weighted average shares used to compute net loss per share, basic
Weighted average shares outstanding used in computing net loss per share, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Employee Stock [Member]
2020 Employee Stock Purchase Plan
Reserved for Future ESPP Issuances
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities:
Research and Development Expense, Policy [Policy Text Block]
Research and Development Costs
Lessee, Operating Lease, Description
Operating lease, description
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Unit Activity
Statement [Table]
Statement [Table]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Schedule of Fair Value of Stock Options Estimated on Date of Grant Using Quoted Market Price For Common Stock On The Applicable Grant Date And Black-Scholes Option Pricing Model
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Document Fiscal Period Focus
Document Fiscal Period Focus
Lessee, Operating Lease, Liability, to be Paid
Total undiscounted future minimum lease payments
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
Statement [Line Items]
Statement [Line Items]
Deferred tax assets Section 174 capitalized R&D.
Deferred Tax Assets section one seventy four Capitalized Research and development
Section 174 Capitalized R&D
NK Cell Products
NK Cell Products [Member]
NK cell products.
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of earnings per share
Balance, January 1, 2020
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Balance, December 31, 2020
Estimated fair value of preferred stock purchase right liability
Collaboration Agreement [Abstract]
Collaboration agreement.
Lease, Cost
Total lease expense
Letters of Credit Outstanding, Amount
Letters of credit outstanding amount
Income tax reconciliation permanent items.
Income Tax Reconciliation Permanent Items
Permanent items
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Significant Components of Deferred Tax Assets
Two thousand twenty performance incentive and two thousand fifteen equity incentive plan.
Two Thousand Twenty Performance Incentive And Two Thousand Fifteen Equity Incentive Plan [Member]
2020 Plan and 2015 Plan
Common Stock [Member]
Common Stock
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Acquisitions of property and equipment recorded in accounts payable and accrued and other current liabilities
Noncash Or Part Noncash Acquisition Fixed Assets Acquired Recorded In Accounts Payable And Accrued And Other Current Liabilities
Noncash or part noncash acquisition fixed assets acquired recorded in accounts payable and accrued and other current liabilities.
Computers and software.
Computers And Software [Member]
Computers and Software
Other Assets, Current
Other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate intrinsic value, exercisable
Accretion (Amortization) of Discounts and Premiums, Investments
Accretion of discount and amortization of premium on investments, net
Prepaid Expense, Current, Total
Prepaid Expense, Current
Prepaid expenses
Stock issued during period shares vesting of shares of common stock subject to repurchase.
Stock Issued During Period Shares Vesting Of Shares Of Common Stock Subject To Repurchase
Vesting of shares of common stock subject to repurchase, Shares
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Loss Contingency Accrual, Ending Balance
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual
Liability regard to loss contingencies
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Accounting Standards Update 2016-13 [Member]
ASU 2016-13
Stock Issued During Period, Value, Conversion of Convertible Securities
Conversion of convertible preferred stock to common stock
Net sales milestone payments
Net Sales Milestone Payments
Net sales milestone payments.
Annual license maintenance fee.
Annual License Maintenance Fee
Annual license maintenance fee
Collaborative Arrangements
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Cover
Cover [Abstract]
Share based compensation arrangement by share based payment award offering period.
Share Based Compensation Arrangement By Share Based Payment Award Offering Period
Offering period
Document Fiscal Year Focus
Document Fiscal Year Focus
Lease commencement date
LeaseCommencementDate
Lease Commencement Date
Lease commencement date.
Sale of Stock [Domain]
Sale of Stock
Share-Based Payment Arrangement [Policy Text Block]
Share-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value for the ESPP
Weighted-average grant date fair value per share, granted
Security Exchange Name
Security Exchange Name
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Contractual term of options granted
Domestic Tax Authority [Member]
Federal
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Preferred Stock, Shares Issued, Total
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Other Long-Term Investments [Member]
Potential future payments
Potential Future Payments Based On Achievement Of Milestones
Potential future payments based on achievement of milestones.
Total property and equipment, gross
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating leases
Right-of-use assets obtained in exchange for operating lease liabilities
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-average exercise price, forfeited
License agreement upfront payment.
License Agreement Upfront Payment
Upfront payment
Financial Instrument [Axis]
Financial Instrument
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Monthly base rent
Monthly Base Rent
Monthly base rent.
Issuance of common stock upon exercise of stock option
Stock Issued During Period, Value, Stock Options Exercised
Entity Emerging Growth Company
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Intrinsic value of options exercised
Amendment Flag
Amendment Flag
Tax Credit Carryforward, Amount
Tax credit carryforwards
IPO
IPO [Member]
Conversion of Stock, Amount Converted
Temporary equity, conversion of convertible preferred stock to common stock
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Available for sale securities, Unrealized Losses
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development credits
Accounting Standards Update [Domain]
Accounting Standards Update
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
2037
Expiration Year Three [Member]
Expiration year three.
Development and Regulatory Approval Milestones
Development and Regulatory Approval Milestones [Member]
Development and regulatory approval milestones.
Payments to Acquire Debt Securities, Available-for-Sale
Purchases of available-for-sale securities
Leases [Abstract]
Tax Period [Domain]
Tax Period
Entity File Number
Entity File Number
Cash received for tenant improvement allowances to be repaid
Cash Received for Tenant Improvement Allowances to be Repaid
Cash received for tenant improvement allowances to be repaid.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research Collaboration Agreement
Research Collaboration Agreement [Member]
Research collaboration agreement.
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Deferred Tax Assets, Gross
Total deferred tax assets
Non-Rule 10b5-1 Arrangement Modified
Non-Rule 10b5-1 Arr Modified [Flag]
Non-Rule 10b5-1 ArrModified Flag.
Stock issued during period shares issued upfront payments.
Stock Issued During Period Shares Issued Upfront Payments
Upfront payment, shares issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Aggregate intrinsic value, vested and expected to vest
Unrealized gain (loss) on investments
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized loss on securities
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Beginning Balance
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Total cash, cash equivalents and restricted cash
Balance Sheet Related Disclosures [Abstract]
Share-Based Payment Arrangement [Abstract]
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share, outstanding beginning balance
Weighted-average grant date fair value per share, outstanding ending balance
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets, Valuation Allowance
Valuation allowance for deferred tax assets
Operating Expenses
Total operating expenses
Auditor Location
Third amendment
Third Amendment [Member]
Third amendment.
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Stockholders' Equity, Reverse Stock Split
Description of the reverse stock split
Entity Address, Address Line Two
Entity Address, Address Line Two
Preferred stock, $0.0001 par value; 54,350,179 shares authorized; no shares issued and outstanding at December 31, 2023 and 2022
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Number of Operating Segments
Number of operating segments
Title of Individual [Axis]
Title of Individual
Investment Type [Axis]
Investment Type
Number of non-exclusive rights to gene editing targets
Number of Non Exclusive Rights to Gene Editing Targets
Number of non exclusive rights to gene editing targets.
Lessee operating lease lease not yet commenced minimum lease payments.
Lessee Operating Lease Lease Not Yet Commenced Minimum Lease Payments
Operating lease not yet commenced minimum lease payments
Purchases of investments
Payments to Acquire Investments
Payments to Acquire Investments, Total
Earnings Per Share [Text Block]
Net Loss Per Share
Commercial Paper [Member]
Commercial Paper
Entity Address, Address Line One
Entity Address, Address Line One
Cash and Cash Equivalents, Fair Value Disclosure
Investments
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Antidilutive Securities [Axis]
Antidilutive Securities
At the market offering
At The Market Offering [Member]
At-the-market offering
Reduction in Force
Reduction in Force [Text Block]
Reduction in force.
Reduction initiation date
Restructuring and Related Activities, Initiation Date
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Components
Restricted Cash, Total
Restricted Cash
Restricted cash
Subsequent Event Type [Domain]
Subsequent Event Type
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Income Statement Location [Axis]
Income Statement Location
Variable Lease, Cost
Variable lease expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued expenses
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Estimated dividend yield
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
2028
Lessee, Operating Lease, Liability, to be Paid, Year Five
Fair Value, Inputs, Level 2 [Member]
Significant Other Observable Inputs (Level 2)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Shares issued
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Depreciation, Depletion and Amortization, Total
Depreciation, Depletion and Amortization
Depreciation and amortization expense
Product and Service [Axis]
Product and Service
Title of 12(b) Security
Title of 12(b) Security
Accrued research and development costs current.
Accrued Research And Development Costs Current
Accrued research and development costs
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State income tax, net of federal benefit
Chief Financial Officer [Member]
Matthew Plunkett
ROU assets obtained in exchange for operating lease liabilities resulting from modifications of existing leases
Right-of-use assets obtained in exchange for operating lease liabilities resulting from modifications of existing leases.
Right-of-use Assets Obtained in Exchange for Operating Lease Liabilities Resulting from Modifications of Existing Leases
Agreement with financial institution.
Agreement With Financial Institution [Member]
Agreement with Financial Institution
Lease Contractual Term [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Maximum percentage of employee compensation eligible for plan
Money Market Funds, at Carrying Value
Money market funds
Investments [Domain]
Investments
Accounting Standards Update [Axis]
Accounting Standards Update
Increase (Decrease) in accounts payable and accrued and other liabilities.
Increase Decrease In Accounts Payable And Accrued And Other Liabilities
Accounts payable and accrued and other liabilities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities:
Accounts Payable and Accrued Liabilities, Current
Total accrued and other liabilities
State and Local Jurisdiction [Member]
California State
Letter of credit
Long-Term Line of Credit
Long-Term Line of Credit, Total
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Annual research license fees and Commercialization license fees
Annual Research License Fees and Commercialization License Fees
Annual research license fees and Commercialization license fees.
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Reduction in Force [Abstract]
Reduction in force.
Temporary equity, preferred stock purchase right (liability) reversal upon issuance of convertible securities.
Temporary Equity Preferred Stock Purchase Right Liability Reversal Upon Issuance Of Convertible Securities
Temporary equity, series B preferred stock purchase right (liability) upon issuance of Series B convertible preferred stock
Unvested common stock upon early exercise of common stock options.
Unvested Common Stock Upon Early Exercise Of Common Stock Options [Member]
Unvested Common Stock Upon Early Exercise of Common Stock Options
Guarantor Obligations, Current Carrying Value
Liabilities recorded for agreements
Commercial Paper, at Carrying Value
Commercial paper
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted-average remaining contractual term (in years), exercisable
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Stock Repurchase Program, Number of Shares Authorized to be Repurchased
Shares subject to repurchase
Share-Based Payment Arrangement [Text Block]
Share-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share, forfeited
Reduction costs
Restructuring Costs
Restructuring Costs, Total
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Retirement Plan Type [Axis]
Retirement Plan Type
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Estimated subtenant rate
Lessee, Operating Lease, Discount Rate
Income Statement Location [Domain]
Income Statement Location
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted-average exercise price, granted
Document Type
Document Type
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of convertible preferred stock to common stock, Shares
Conversion of convertible preferred stock to common stock
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Counterparty Name [Domain]
Counterparty Name
Temporary equity stock issued during period shares new issues.
Temporary Equity Stock Issued During Period Shares New Issues
Temporary equity, Issuance of Series B convertible preferred stock, net of issuance costs, Shares
Sale of preferred stock, net of issuance costs, Shares
Security deposit
Security Deposit
Proceeds from secondary offering net of issuance costs.
Proceeds From Secondary Offering Net Of Issuance Costs
Proceeds from secondary offering, net of issuance costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of shares, forfeited
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Summary of common stock reserved for future issuance.
Summary Of Common Stock Reserved For Future Issuance Table [Text Block]
Summary of Common Stock Reserved For Future Issuance
Short-Term Investments [Member]
Short-term investments
Entity Filer Category
Entity Filer Category
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Balance Sheet Location [Domain]
ROU asset impairment
Impairment of right-of-use assets
Operating Lease, Impairment Loss
Cash cash equivalents short term investments and restricted cash.
Cash Cash Equivalents Short Term Investments And Restricted Cash Policy [Text Block]
Cash, Cash Equivalents, Short-term Investments and Restricted Cash
Short-term investments
Short-term Investments, Total
Short-Term Investments
Total short-term investments
Total other income, net
Nonoperating Income (Expense)
Liabilities
Total liabilities
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Tenant improvement allowances yet to receive
Tenant Improvements Yet To Receive From Lessor
Tenant improvements yet to receive from lessor.
Unusual or infrequent items disclosure.
Unusual Or Infrequent Items Disclosure Policy [Text Block]
COVID-19 Pandemic
Total stockholders' equity
Equity, Attributable to Parent
Ending Balance
Beginning Balance
Defined Contribution Plan, Description
Defined contribution plan, description
Debt Securities, Available-for-Sale, Realized Loss
Realized loss on investments
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Net loss
Net loss
Other income, net:
Nonoperating Income (Expense) [Abstract]
Accrued property and equipment liabilities current.
Accrued Property And Equipment Liabilities Current
Accrued property and equipment
Proceeds from Issuance Initial Public Offering
Proceeds from initial public offering, net of issuance costs
Proceeds from issuance initial public offering
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents
Corporate Debt Securities [Member]
Corporate Debt Securities
Fair Value Measurement, Policy [Policy Text Block]
Fair Value of Financial Instruments
Statement of Financial Position [Abstract]
Weighted average shares used to compute net loss per share, diluted
Weighted average shares outstanding used in computing net loss per share, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
After year two.
After Year Two [Member]
After Year Two of the Agreement
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Reconciliation on Income Taxes Amount Computed by Applying Statutory Federal Income Tax Rate to Net Loss
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash lease expense
Impairments.
Impairments
Impairments
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Schedule of Accrued Other Current Liabilities
Debt Securities, Available-for-Sale, Amortized Cost
Available for sale securities, Amortized Cost
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Commons stock purchase price as percentage of fair value
Deferred offering costs liabilities current.
Deferred Offering Costs Liabilities Current
Deferred offering costs
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Income Tax Disclosure [Text Block]
Income Taxes
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-average exercise price, outstanding ending balance
Weighted-average exercise price, outstanding beginning balance
Follow On Offering of Stock
Follow On Offering of Stock [Member]
Follow on offering of stock.
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Computation of Basic and Diluted Net Loss Per Share
Leasehold Improvements [Member]
Leasehold Improvements
Income Tax Authority [Axis]
Income Tax Authority
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Fair value of common stock issued.
Fair Value Of Common Stock Issued
Fair value of common stock issued
Fair Value Disclosures [Abstract]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Purchase of property and equipment
Number of shares, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of shares, vested
Issuance of common stock, net of issuance costs, Shares
Stock Issued During Period, Shares, New Issues
Common stock shares issued and sold
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Accrued compensation
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash at end of year
Cash, cash equivalents and restricted cash at beginning of year
Income Tax Disclosure [Abstract]
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Operating Loss Carryforwards, Total
Operating Loss Carryforwards
Net operating loss carryforwards